CAS 1290543-63-3: Nirogacestat
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- CAS Number: 1290543-63-3
- Stock： 250g
- Assay: 99.50%
Nirogacestat, CAS 1290543-63-3
Nirogacestat, CAS 1290543-63-3, 库存 250g, 含量 99.5%, 白色粉末, 水 0.54%, 单一杂质 0.5%.
Nirogacestat
Nirogacestat，也被称为PF-03084014，是一种有效的选择性γ分泌酶(GS)抑制剂，具有潜在的抗肿瘤活性。PF-03084014结合GS，阻断Notch受体的蛋白水解激活。硝加司他增强多西紫杉醇对前列腺癌的抗肿瘤作用。硝加司他增强了多西他赛介导的肿瘤反应，并为探索GSIs与多西他赛联合治疗CRPC(阉割抵抗性前列腺癌)提供了理论依据。
产品详情:
Name: Nirogacestat free base
CAS#: 1290543-63-3 (free base)
Chemical Formula: C27H41F2N5O
Exact Mass: 489.32792
Molecular Weight: 489.65581
Elemental Analysis: C, 66.23; H, 8.44; F, 7.76; N, 14.30; O, 3.27
Specification:
Synonym: PF-03084014; PF03084014; PF 03084014; PF-3084014; PF3084014; PF 3084014; Nirogacestat
IUPAC/Chemical Name: (S)-2-(((S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)amino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide
InChi Key: VFCRKLWBYMDAED-REWPJTCUSA-N
InChi Code: InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1
SMILES Code: CCC[C@H](N[C@@H]1CC2=C(C=C(F)C=C2F)CC1)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
Certification:
